This project is led by Professor Zofia Miedzybrodzka, Professor in Medical Genetics at the University of Aberdeen and Professor Russell Petty, Professor of Medical Oncology, Clinical and Translational Research in Oesophageal and Gastric Cancer at Ninewells Hospital in Dundee.
An unmet clinical need. Oesophageal Cancer (OC) is a highly aggressive common form of cancer with a rising incidence worldwide and poor prognosis. Median survival remains only 10 months following surgery and/or chemotherapy. In the UK, survival rates are 40 % reducing to 15 % at 5 years. The rising incidence and poor clinical outcomes with current therapeutic approaches mean that there is a real need for new treatments but also a need for improved use of currently available therapies.
Objectives of this project are five-fold:
Using the SMS Innovation Platform, exome panel-based sequencing has been carried out on DNA samples provided by the University of Aberdeen and NHS Grampian. Bio-informatics analysis will be performed using the SMS Innovation Platform. These outputs will then be used to assess for a diagnostic response.BACK TO PROJECTS